Recent studies have demonstrated that drug antimicrobial activity is enhanced when metallic nanoparticles are used as an\ninorganic support, obtaining synergic effects against microorganisms. The cationic antimicrobial peptide ubiquicidin 29ââ?¬â??41\n(UBI) has demonstrated high affinity and sensitivity towards fungal and bacterial infections. The aim of this research was\nto prepare and evaluate the antimicrobial efficacy of engineered multivalent nanoparticle systems based on silver or gold\nnanoparticles functionalized with UBI. Spectroscopy techniques demonstrated that NPs were functionalized with UBI mainly\nthrough interactions with the -NH2 groups. A significant increase in the antibacterial activity against Escherichia coli and\nPseudomonas aeruginosa was obtained with the conjugate AgNP-UBI with regard to that of AgNP.No inhibition of bacterial growth\nwas observed withAuNP andAuNP-UBI using a nanoparticle concentration of up to 182
Loading....